Suspension Preparation

Introduction

A pharmaceutical suspension is a liquid dosage form that contains finely divided insoluble materials which are distributed evenly within the suspending medium offering a degree of solubility. This dosage form is normally used when it is needed to provide a liquid dosage form for a poorly soluble drug. Additionally, it is ideal for drugs that become unstable in an aqueous medium over time. There are a number of ways that a suspension can be administered such as, orally, injection, and even application to the skin.

 

In this guide, we will go over how to make a suspension.

How to make a suspension

Needed equipment

1: Mortar and pestle

2: Rubber spatula

3: Metal spatula

4: Graduated conical

5: Prescription bottle

6: Weigh boats

 

Step 1: Place the specified number of  tablets in your mortar and triturate until the tablets have become a fine powder.

*Using a firm twisting motion is the most efficient way to start the trituration process.

 

Step 2: Place your weigh boat on to the scale then tare the scale to zero.

 

Step 3: Place the powder into the weigh boat until you have the specified weight.

*Be sure to dispose of the remaining powder in the appropriate manner.

 

Step 4: Measure the required amount of suspending agent (Be sure to shake the suspending agent well before measuring) by pouring into your graduated conical.

 

Step 5: Create a divot in the center of your powder by firmly pressing down with your pestle. Pour a small amount of the suspending agent into the center of the divot. Use the pestle to begin the wetting process. *Rubber spatula can be sued if scraping is necessary.

 

Step 6: Continue to pour small amounts of the suspending agent into the mortar. *It is important to add the suspending agent otherwise clumping may occur in the suspension. *Use the rubber spatula to scrap your pestle and the sides of the mortar.

 

Step 7: Continue adding the suspending agent until you have until there is a smooth consistent with no lumps. Once the consistency is smooth, you may add the suspending liquid more quickly. *The suspension should have no lumps inside.

 

Step 8: Pour your completed suspension into your prescription bottle. *Use the rubber spatula to scrap and remove all of the suspension from the mortar.

 

Step 9: Once you have finished placing all of the completed solution into the prescription bottle you may cap the bottle.

 

Step 10: Clearly label your bottle with the contents.

 

Conclusion

Pharmaceutical suspensions possess some advantages over other dosage forms. Such advantages include being able to create a vehicle for poorly soluble chemicals, being more chemically stable than a solution, and being easier to swallow.

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