A pharmaceutical suspension is a liquid dosage form that contains finely divided insoluble materials which are distributed evenly within the suspending medium offering a degree of solubility. This dosage form is normally used when it is needed to provide a liquid dosage form for a poorly soluble drug. Additionally, it is ideal for drugs that become unstable in an aqueous medium over time. There are a number of ways that a suspension can be administered such as orally, injection, and even application to the skin.
In this guide, we will go over how to make a suspension.
How to make a suspension
- • Mortar and pestle
- • Rubber spatula
- • Metal spatula
- • Graduated conical
- • Prescription bottle
- • Weigh boats
Place the specified number of tablets in your mortar and triturate until the tablets have become a fine powder.
*Using a firm twisting motion is the most efficient way to start the trituration process.
Place your weigh boat onto the scale then tare the scale to zero.
Place the powder into the weigh boat until you have the specified weight.
*Be sure to dispose of the remaining powder in the appropriate manner.
Measure the required amount of suspending agent (Be sure to shake the suspending agent well before measuring) by pouring it into your graduated conical.
Create a divot in the center of your powder by firmly pressing down with your pestle. Pour a small amount of the suspending agent into the center of the divot. Use the pestle to begin the wetting process. *Rubber spatula can be sued if scraping is necessary.
Continue to pour small amounts of the suspending agent into the mortar. *It is important to add the suspending agent otherwise clumping may occur in the suspension. *Use the rubber spatula to scrap your pestle and the sides of the mortar.
Continue adding the suspending agent until there is a smooth consistency with no lumps. Once the consistency is smooth, you may add the suspending liquid more quickly. *The suspension should have no lumps inside.
Pour your completed suspension into your prescription bottle. *Use the rubber spatula to scrape and remove all of the suspension from the mortar.
Once you have finished placing all of the completed solution into the prescription bottle you may cap the bottle.
Clearly label your bottle with the contents.
Pharmaceutical suspensions possess some advantages over other dosage forms. Such advantages include being able to create a vehicle for poorly soluble chemicals, being more chemically stable than a solution, and being easier to swallow.