Phenibut HCL Powder (Small crystal)

Buy Phenibut

Venogen offers certified phenibut HCl powder for sale online for research purposes only.

What is Phenibut?

The GABA derivative Phenibut (4-amino 3-phenylbutanoic acid) is sold online through Venogen in powder form (not as Phenibut capsules) as its acid salt Phenibut HCl (rather than as the free amino acid). It is an analogue of the well-known dietary supplement gamma-aminobutyric acid (GABA). Phenibut differs from it in that it has a phenyl ring substituted at the β-position on the carbon chain. For this reason, it is sometimes also known as beta-phenyl GABA. It first found usage in the former Soviet Union in the treatment of anxiety due to its calming effect [a], and in recent decades, it has been the subject of scientific and popular interest for its potential future uses as a dietary supplement and/or a nootropic drug [b]. Its molecular weight is 179.22, and its molecular formula is C10H13NO2 [c].

Modes of action

Phenibut acts as a GABA mimetic at the GABA-A and GABA-B receptors, especially the latter. It is also reported to stimulate dopamine production and act as a β-phenylethylamine antagonist [d]. The extra phenyl ring makes the substance more lipophilic, improving its ability to cross the blood-brain barrier and affect the central nervous system [e].

Animal Studies

A 2010 study reported that injections of phenibut worked to reduce anxiety in rabbits [f].

A 2015 study found that R-Phenibut had a neuroprotective effect in rats with middle cerebral artery occlusion [g].

Human Studies

As previously mentioned, phenibut has a well-documented history of use in Russia as an anxiolytic [a]. Phenibut (and other nootropics which function as GABA agonists) have been reported to improve sleep quality [h].

Adverse Reactions

Numerous papers have reported withdrawal symptoms (anxiety and psychosis) in patients who had used the Internet to purchase Phenibut and then used the substance on a daily basis for a week or more [b] [i] [j] [k].

Other case studies have documented cases of acute Phenibut overdose. They describe symptoms such as decreased levels of consciousness, hypertension, behavioural disturbance and delirium [a] [l].

Why buy Phenibut online through Venogen?

Our Venogen HCl (and all our other products offered) has been independently audited by batch (lab tested) and produced within a GMP facility. Venogen is a solid choice if you are looking to buy phenibut HCl online (GMP-produced). We are a long-established vendor of analytical research chemicals for laboratory research use, and are proud of our great customer service. Our products are of the highest quality, and we are proud of our fast shipping and excellent customer service. We have quality phenibut powder for sale with high product purity.

Legal Disclaimer

We recommend purchasing phenibut HCl online for laboratory research purposes only, not for human consumption. Although researchers demonstrated that human use of phenibut HCl powder or phenibut HCl capsules may have beneficial effects on the human body in clinical studies, the studies are inconclusive within a proper medical setting and conducted for research purposes only. Further research is required for this substance to be FDA-approved. We offer phenibut powder for sale online as an experimental compound that is not intended for human consumption or veterinary use.

Venogen does not sell phenibut for customers to use for recreational purposes.

If you purchase phenibut, in order to maximise its shelf life, we recommend that you store it in a cool, dry place away from direct sunlight.

References

[a] Li C, Sundararajan K. An uncommon case of phenibut toxicity in an intensive care unit. International Journal of Medical and Pharmaceutical Case Reports. 2015;5(5):1-6. doi:10.9734/ijmpcr/2015/21689

[b] Jouney EA. Phenibut (β-phenyl-γ-aminobutyric acid): An easily obtainable “dietary supplement” with propensities for physical dependence and addiction. Current Psychiatry Reports. 2019;21(4). doi:10.1007/s11920-019-1009-0

[c] 4-amino-3-phenylbutanoic acid. National Center for Biotechnology Information. PubChem Compound Database. https://pubchem.ncbi.nlm.nih.gov/compound/4-Amino-3-phenylbutanoic-acid. Accessed October 4, 2022.

[d] Lapin I. Phenibut (β-phenyl-GABA): A tranquilizer and Nootropic Drug. CNS Drug Reviews. 2006;7(4):471-481. doi:10.1111/j.1527-3458.2001.tb00211.x

[e] Li W, Madhira B. Phenibut (β-phenyl-γ-aminobutyric acid) psychosis. American Journal of Therapeutics. 2017;24(5). doi:10.1097/mjt.0000000000000618

[f] Zyablitseva EA, Pavlova IV. Effects of the GABA receptor agonist phenibut on spike activity and interactions between neocortex and hippocampus neurons in emotionally negative situations. Neuroscience and Behavioral Physiology. 2010;40(9):1003-1011. doi:10.1007/s11055-010-9360-y

[g] Vavers E, Zvejniece L, Svalbe B, et al. The neuroprotective effects of R-phenibut after focal cerebral ischemia. Pharmacological Research. 2016;113:796-801. doi:10.1016/j.phrs.2015.11.013

[h] Shul’gina GI, Zyablitseva EA, Kositsyn NS. The influence of agonists of GABAA and GABAB receptors on the formation of the defensive and inhibitory conditioned reflexes. Doklady Biological Sciences. 2009;429(1):497-499. doi:10.1134/s0012496609060040

[i] Magsalin RM, Khan AY. Withdrawal symptoms after internet purchase of phenibut (β-phenyl-γ-aminobutyric acid hcl). Journal of Clinical Psychopharmacology. 2010;30(5):648-649. doi:10.1097/jcp.0b013e3181f057c8

[j] Högberg L, Szabó I, Ruusa J. Psychotic symptoms during phenibut (beta-phenyl-gamma-aminobutyric acid) withdrawal. Journal of Substance Use. 2012;18(4):335-338. doi:10.3109/14659891.2012.668261

[k] Phenibut (β-Phenyl-γ-aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse

[l] Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK. Acute behavioural disturbance associated with Phenibut purchased via an internet supplier. Clinical Toxicology. 2015;53(7):636-638. doi:10.3109/15563650.2015.1059945