4-Amino-3-(4-fluorophenyl)butanoic acid hydrochloride (F-phenibut HCl)

Buy F-Phenibut HCL

Venogen sells certified F-phenibut HCl powder (CAS No. 1858241-03-8) online for research purposes only.

What is F-Phenibut?

F-phenibut, also known as β-(4-Fluorophenyl)-GABA, is a derivative of the GABA analogue phenibut and is sold online through Venogen in powder form (not as Phenibut capsules) as its acid salt F-Phenibut HCl (not as the free amino acid). Phenibut was first discovered in the former Soviet Union in the 1960s when researchers found its nootropic and anxiolytic effects [a].

F-phenibut is similar to phenibut but has an additional fluorine atom at the β-position of its phenyl group. This increases its affinity for GABA B receptors and may enhance its neurological and pharmacological effects [b] [c].

F-phenibut is not for clinical use; it is a research chemical.

• Molecular weight: 233.67,
• Molecular formula: C10H13CIFNO2 [d].

Modes of Action

Phenibut stimulates dopamine receptors and balances the anxiety inducing effects of β-phenethylamine. It mimics GABA by primarily targeting GABA B receptors, with some activity at GABA A receptors [a]. F-Phenibut also targets GABA B receptors but is reported to be more potent [c].

A study in the European Journal of Pharmacology found that F-Phenibut is more potent than phenibut (23.3 μM vs. 1362 μM) – with a potency ratio of 1:58. F-Phenibut also suppresses action potential generation in Purkinje cells; it can significantly inhibit neuronal excitability [c].

Although the higher affinity and potent GABA B receptor activation of F-phenibut is clear, the mechanism of action on neuronal function is unknown [c].

Animal Studies

There are no specific studies on F-phenibut in animal models, but it is presumed to have the same effects as phenibut, which has anxiolytic and nootropic effects in animal studies [a].

A 2020 study of F-phenibut on mice cerebellar Purkinje cells using in vitro patch-clamp recordings found that F-phenibut was more potent than phenibut but less potent than baclofen. F-phenibut induced an outward-rectifying potassium (K+) current that was not affected by various ions and inhibitors. F-phenibut also suppressed action potential generation in these neurons; it could lead to severe neurological damage due to its strong inhibition of neuronal excitability [c].

Human Studies

There is no documented human study on F-phenibut, so handle with care in controlled research settings only.

Adverse Reactions

Many studies have reported withdrawal symptoms (anxiety and psychosis) in patients who bought phenibut online and used it for a week or more. There have been reports of acute phenibut overdose, which can cause symptoms like decreased mental state, hypertension, behavioural disturbances, and delirium [e] [f] [g].

Misuse of phenibut can lead to negative effects. This is often done at dosages of 0.5–100 g/day, as opposed to the therapeutic range of 0.25–2 g/day [g]. Combining phenibut with alcohol can prolong and worsen withdrawal syndrome, making withdrawal more complicated and increasing the risk of severe side effects [f] [h].

Similarly, F-phenibut can lead to tolerance, dependence, and withdrawal symptoms. A study found that F-Phenibut suppresses action potential generation in mouse cerebellar Purkinje cells. This means even at lower doses, F-Phenibut abuse can cause more severe motor dysfunction than phenibut abuse [c].

However, more research and case studies are required to fully comprehend the risks and safety of F-Phenibut [b] [c]

Why purchase F-Phenibut HCL from Venogen?

Our Venogen F-Phenibut HCl (and all our products) have been batch tested (lab tested) and are produced in a GMP facility. If you want to order F-Phenibut HCl online (GMP-produced), then Venogen is your first choice.

We are a long-established vendor of analytical research chemicals for laboratory use. Our products are top quality, and we are proud of our fast shipping and excellent customer service. We have F-Phenibut powder for sale with high product purity.

Legal Disclaimer

We recommend to source F-Phenibut HCl online for laboratory research use only, not for human consumption. Although researchers have shown that human use of F-Phenibut HCl powder or F-Phenibut HCl capsules may have benefits in clinical studies, these studies are not conclusive and are for research use only. More research is needed for this substance to be FDA-approved. We sell F-Phenibut powder online as an experimental compound, not for human or veterinary use.

Venogen does not sell F-Phenibut for recreational use and does not condone the misuse of any of its products.

To maximise shelf life, store F-phenibut HCl in a cool dry place away from direct sunlight.

References

[a] Lapin I. Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2001 Winter;7(4):471-81. doi: 10.1111/j.1527-3458.2001.tb00211.x. PMID: 11830761; PMCID: PMC6494145.

[b] Binkley, Z., Logan, R., & Treml, J. (2022). Assessing Phenibut’s Inhibition of Glutamate Induced Apoptosis in SHSY5Y cells, an in Vitro Model for Traumatic Brain Injury. Midwestern Journal of Undergraduate Sciences, 1(1). [https://doi.org/10.17161/mjusc.v1i1.18557]

[c] Irie T, Yamazaki D, Kikura-Hanajiri R. F-phenibut (β-(4-Fluorophenyl)-GABA), a potent GABA B receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells. Eur J Pharmacol. 2020 Oct 5;884:173437. doi: 10.1016/j.ejphar.2020.173437. Epub 2020 Jul 28. PMID: 32735986. [https://pubmed.ncbi.nlm.nih.gov/32735986/]

[d] National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 121237598, 4-Amino-3-(4-fluorophenyl)butanoic acid hydrochloride. Retrieved July 18, 2024 from [https://pubchem.ncbi.nlm.nih.gov/compound/121237598]

[e] Kupats, E., Vrublevska, J., Zvejniece, B., Vavers, E., Stelfa, G., Zvejniece, L., & Dambrova, M. (2020). Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports. Pharmacopsychiatry, 53(05), 201–208. [https://doi.org/10.1055/a-1151-5017]

[f] Ahuja, T., Mgbako, O., Katzman, C., & Grossman, A. (2018). Phenibut (β-Phenyl-γ-aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse. Case Reports in Psychiatry, 2018, 1–3. [https://doi.org/10.1155/2018/9864285]

[g] Li, C., & Sundararajan, K. (2015). An Uncommon Case of Phenibut Toxicity in an Intensive Care Unit. International Journal of Medical and Pharmaceutical Case Reports, 5(5), 1–6. [https://doi.org/10.9734/ijmpcr/2015/21689]

[h] Zheng, K. H., Khan, A., & Espiridion, E. D. (2019). Phenibut Addiction in a Patient with Substance Use Disorder. Cureus. [https://doi.org/10.7759/cureus.5230]