GW 501516 (Cardarine, Endurobol)

USD $70.00 Bulk Pricing

WARNING: This product is not for human or veterinary use.

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Product Description

Venogen offers certified GW501516 for sale online in 10mg reference standards, for research purposes only.

What is GW-501516?

GW501516 is research chemical, belonging to the class of drugs known as Selective Androgen Receptor Modulators (SARMs). GW-501516 is a research chemical trademarked under the name Cardarine by Matsudo LTD. It is also known as Endurobol. GW-501516 has a molecular weight of 450.2 grams per mole, and a molecular formula of C21H18F3NO3S2 [a]. It is a PPAR agonist with a high affinity as a PPAR-δ ligand [b]. Researchers speculate that PPAR agonists “may have therapeutic utility in the treatment of hyperlipidemia, atherosclerosis, and obesity.” Human consumption of a Selective Androgen Receptor Modulator (such as the GW-501516 Cardarine for sale online through Venogen) may therefore be indicated in the future for those seeking a to achieve a better ratio of body fat to muscle mass through fat burning. Researchers have also discussed the potential use of GW501516 Cardarine in controlling insulin resistance [c]. Due to their effect of preserving glucose, PPAR agonists may also see future use not only to combat obesity through fat loss, but also by athletes seeking higher energy levels, e.g. in enhancing running endurance and other forms of muscular endurance [d].

Modes of action

PPAR is expressed in both adipose tissue and skeletal muscle tissue, and is involved in the regulation of energy expenditure in those tissues. In vivo studies have reported a link between stimulation of these receptors and increased glucose tolerance [c]. Skeletal muscle tissue is known to be involved in fatty acid oxidation, preferential lipid utilization and HDL cholesterol efflux (“good cholesterol”).

Animal Studies

A 2003 study in mice reported that Cardarine GW 501516 increased fatty acid oxidation in obese mice that had been fed a high-fat diet. When GW 501516 was administered to the obese mice, they were also found to have lower levels both fasting insulin and insulin after feeding. The animal trial also found promising results regarding selectivity, namely that it was linked to a much higher amount of muscle gene expression as compared to genes involved with fatty acid oxidation in the liver. [e].

A 2007 study replicated the finding that GW501516 promoted fatty acid oxidation in mice [f].

A 2012 study found that GW-501516 slowed weight gain in rhesus monkeys where HDL cholesterol levels had been suppresed by means of a high fat diet. It also found that GW 501516 caused statistically significant decreases in total cholesterol, triglycerides, low density lipoproteins, APO-B100, and insulin [5]. All of these are known to have deletrious effects on heart health in monkeys, humans and other animals [g].

A 2015 trial found that administration of GW-501516 to Kunming mice led to improved performance on endurance tests [h].

Human Studies

No clinical trials of GW-501516 have been conducted on humans at present.

Why buy Cardarine online through Venogen?

All Venogen chemicals (in all product categories) have been independently audited by batch and produced within a GMP facility. Venogen is a solid choice if you are looking to buy GW-501516 online (GMP produced). We are a long-established vendor of analytical research chemicals for laboratory research use, and are proud of our great customer service. Our products are of the highest quality, and we are proud of our fast shipping and excellent customer service. We have quality GW-501516 Cardarine for purchase with a high product purity.

Disclaimer

We recommend to buy GW-501516 Cardarine online for laboratory research purposes only, not for human consumption. Although researchers demonstrated that human use of GW-501516 Cardarine may have beneficial effects on the human body in clinical studies, the studies are inconclusive within a proper medical setting and conducted for research purposes only. We offer Cardarine GW-501516 for sale online as an experimental compound that is not intended for Human or Veterinarian use.

If you are seeking to grow muscle or to achieve weight loss by losing body fat, Venogen recommends that you achieve this through a combination of exercise and controlling the food that you eat.

If you purchase GW-501516, in order to maximise its shelf life, we recommend that you store it in a cool dry place away from direct sunlight.

Note that Cardarine has been classified as a Schedule 9 compound in Australia.

References

[a] Endurobol. National Center for Biotechnology Information. PubChem Compound Database. https://pubchem.ncbi.nlm.nih.gov/compound/Endurobol. Accessed August 3, 2022.

[b] Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth. Nature Medicine. 2004;10(3):245-247. doi:10.1038/nm993

[c] Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE. The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Molecular Endocrinology. 2003;17(12):2477-2493. doi:10.1210/me.2003-0151

[d] Fan W, Waizenegger W, Lin CS, et al. PPARδ promotes running endurance by preserving glucose. Cell Metabolism. 2017;25(5). doi:10.1016/j.cmet.2017.04.006

[e] Tanaka T, Yamamoto J, Iwasaki S, et al. Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome. Proceedings of the National Academy of Sciences. 2003;100(26):15924-15929. doi:10.1073/pnas.0306981100

[f] Dimopoulos N, Watson M, Green C, Hundal HS. The PPARΔ agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat l6 skeletal muscle cells. FEBS Letters. 2007;581(24):4743-4748. doi:10.1016/j.febslet.2007.08.072

[g] Luo Q-H, Zeng W, Chen Z-L, et al. The effect of PPARΔ agonists (HS00098) on serum lipid profiles in diet-induced obese rhesus monkeys. Journal of Biomedical Science and Engineering. 2012;05(08):439-447. doi:10.4236/jbise.2012.58056

[h] Chen W, Gao R, Xie X, et al. A metabolomic study of the PPARΔ agonist GW501516 for enhancing running endurance in Kunming mice. Scientific Reports. 2015;5(1). doi:10.1038/srep09884

Technical Information and Resources

 

Formula Weight: 453.5
Molecular formula: C21H18F3NO3S2
λmax: 201, 318 nm
InChIKey: YDBLKRPLXZNVNB-UHFFFAOYSA-N
Pubchem Compund ID: 9803963

Product Information

CAS
317318-70-0
Form
Tablet
UNII
7I2HA1NU22
EINECS
N/A
Purity
99%
Stability
≥ 2 years