RAD140 (Testolone)

USD $65.00 Bulk Pricing

WARNING: This product is not for human or veterinary use.

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Product Description

Venogen offers certified GMP RAD-140 for sale online in 10mg reference standards, for research purposes only.

What is RAD-140?

RAD-140 is a type of drug known as a Selective Androgen Receptor Modulator (SARM). RAD-140 is a research chemical trademarked under the name Testolone by Matsudo Ltd. RAD 140 Testolone has a molecular weight of 393.83 and a molecular formula of C20H16ClN5O2 [a]. Clinical research suggests that the androgenic activity of selective androgen receptor modulators (such as the RAD 140 Testolone for sale online through Venogen) may indicate their future applications in the treatment of muscle wasting and osteoporosis [b] [c] In particular, Testolone RAD-140 may have benefits for breast cancer patients not only due to its ability to build lean muscle mass, but also because it may affect tumors directly [d]. Researchers discussed the potential benefits of SARMs (such as RAD-140) in general to treat osteoporosis (decreased density of bone tissues), and the potential use of RAD-140 in particular to treat diseases such as Alzheimer’s disease [e].

Modes of action

Selective Androgen Receptor Modulators (such as the Testolone RAD-140 for sale through this website) bind as ligands to androgen receptors (AR) in a tissue selective fashion, binding preferentially to ARs in lean muscle and bone tissue to achieve androgenic effects, while avoiding binding to ARs in tissue such as the prostate (which can negatively affect it) [c]. RAD-140 has a long half life prior to elimination of the drug from the human body. [d]

Animal Research

It is common practice to conduct animal studies prior to any clinical research in humans, and RAD140 is no exception. A 2010 study in rats and primates found that RAD140 had an excellent affinity for androgen receptors in muscle tissue, with less stimulation of ARs in the prostate, and acting as an antagonist on ARs in the seminal vesicles. It found that RAD-140 has benefits on muscle mass even at low doses [f].

A 2014 study found that RAD-140 had a neuroprotective effect on hippocampal neurons in rat brain tissue, both in vitro and in vivo [g].

Human Research

A 2020 study of RAD 140 Testolone found that has potential in the treatment of breast cancer, by virtue of the fact that it is an androgen receptor agonist. The authors reported an elimination half life of 45 hours for RAD 140 [d]

There are case studies documenting negative side effects following human consumption of Testolone RAD-140 and other SARMs. In a 2020 paper, the authors review cases of liver injury following human consumption of two SARMs, one of which was RAD-140 Testolone [h]. Another 2022 paper documents a similar incident of liver injury in a patient who had consumed Testolone RAD-140 [i]. In a 2022 paper, the authors review the history of adverse events in people who buy RAD-140 Testolone, noting that most users buy RAD 140 Testolone to build muscle mass [j]. It is noteworthy that it took some time for these side effects to appear after the patients began to consume RAD 140 Testolone. None of them were evident in the first week of use of Testolone RAD 140.

A 2022 review does a review of the growing misuse of SARMs such as RAD-140. It describes how gym-goers buy RAD-140 online (and similar substances) to use to build muscle mass. There is a community of social media influencers targeting those seeking to improve their body fat percentage by means other than working out and consuming healthy food. Although neither RAD 140 nor any other selective androgen receptor modulator is intended for human consumption at this time (consumers can only buy RAD-140 online for research purposes), these influencers review supplements and recommend that their followers purchase RAD-140 online (and other SARMs). They review its purported benefits such as “great muscle stimulation”, “increased endurance”, “huge energy benefits”, “burn fat fast” and how it can improve the body’s ratio of muscle to body fat [k].

A 2021 cross-sectional study conducted a review of side effects of RAD-140 and other SARMs, and reports occasional instances of hair loss [l]. Another 2009 review of SARMs (though not RAD-140) also reported instances of hair loss [m].

A 2022 study also documented a case of myocarditis in a man who had used RAD-140 Testolone to build muscle mass [n].

Why buy RAD-140 Testolone online through Venogen?

All Venogen chemicals (in all product categories) have been independently audited by batch and produced within a GMP facility. Venogen is a solid choice if you are looking to buy RAD-140 online (GMP produced). We are a long-established vendor of analytical research chemicals for laboratory research use, and are proud of our great customer service. Our products are of the highest quality, and we are proud of our fast shipping and excellent customer service. We have quality RAD 140 Testolone for sale with a high product purity.

Disclaimer

We recommend to buy RAD 140 online for laboratory research use only. Although researchers demonstrated that human use of RAD-140 Testolone may have beneficial effects on the human body in clinical studies, the studies are inconclusive within a proper medical setting and conducted for research purposes only. We offer Testolone RAD140 for sale online as an experimental compound that is not intended for Human or Veterinarian use.

If you are seeking to grow muscle or to achieve weight loss by losing body fat, Venogen recommends that you achieve this through a combination of exercise and controlling the food that you eat.

If you purchase RAD-140, in order to maximise its shelf life, we recommend that you store it in a cool dry place away from direct sunlight.

##References

[a] 2-chloro-4-[[(1r,2s)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile. CAS Common Chemistry. https://commonchemistry.cas.org/detail?cas_rn=1182367-47-0. Accessed July 30, 2022.

[b] Fonseca GW, Dworatzek E, Ebner N, Von Haehling S. Selective androgen receptor modulators (sarms) as pharmacological treatment for muscle wasting in ongoing clinical trials. Expert Opinion on Investigational Drugs. 2020;29(8):881-891. doi:10.1080/13543784.2020.1777275

[c] Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective androgen receptor modulators: Current knowledge and clinical applications. Sexual Medicine Reviews. 2019;7(1):84-94. doi:10.1016/j.sxmr.2018.09.006

[d] Hamilton E, LoRusso P, Ma C, et al. Abstract P5-11-01 : Phase 1 dose escalation study of a novel selective androgen receptor modulator (SARM), RAD140, in estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-), metastatic breast cancer. Cancer Research. 2020;80(4_Supplement). doi:10.1158/1538-7445.sabcs19-p5-11-01

[e] Vasilev V, Boyadjiev N. Selective androgen receptor modulators (sarms) in sports: A Review. ATHENS JOURNAL OF SPORTS. 2021;8(3):215-230. doi:10.30958/ajspo.8-3-4

[f] Selective androgen receptor modulator RAD140. Definitions. 2020. doi:10.32388/qaxrmo

[g] Jayaraman A, Christensen A, Moser VA, et al. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014;155(4):1398-1406. doi:10.1210/en.2013-1725

[h] Flores JE, Chitturi S, Walker S. Drug‐induced liver injury by selective androgenic receptor modulators. Hepatology Communications. 2020;4(3):450-452. doi:10.1002/hep4.1456

[i] Yaramada P, Goyal P, Hammami M, Cai C. S2399 rad-140: An emerging cause of drug-induced liver injury. American Journal of Gastroenterology. 2020;115(1). doi:10.14309/01.ajg.0000711644.40417.60

[j] Leung K, Yaramada P, Goyal P, Cai CX, Thung I, Hammami MB. Rad-140 drug-induced liver injury. Ochsner Journal. 2022. doi:10.31486/toj.22.0005

[k] Hahamyan HA, Vasireddi N, Voos JE, Calcei JG. Social Media’s impact on widespread Sarms abuse. The Physician and Sportsmedicine. 2022:1-3. doi:10.1080/00913847.2022.2078679

[l] Efimenko IV, Valancy D, Dubin JM, Ramasamy R. Adverse effects and potential benefits among selective androgen receptor modulators users: A cross-sectional survey. International Journal of Impotence Research. 2021. doi:10.1038/s41443-021-00465-0

[m] Mitchell HJ, Dankulich WP, Hartman GD, et al. Design, synthesis, and biological evaluation of 16-substituted 4-Azasteroids as tissue-selective androgen receptor modulators (sarms). Journal of Medicinal Chemistry. 2009;52(15):4578-4581. doi:10.1021/jm900880r

[n] Padappayil RP, Chandini Arjun A, Vivar Acosta J, Ghali W, Mughal MS. Acute myocarditis from the use of selective androgen receptor modulator (SARM) RAD-140 (Testolone). Cureus. 2022. doi:10.7759/cureus.21663

Technical Information and Resources

 

Formula Weight: 393.8
Molecular formula: C20H16ClN5O2
λmax: 231, 277 nm
InChIKey: XMBUPPIEVAFYHO-KPZWWZAWSA-N
Pubchem Compund ID: 44200882

Product Information

CAS
1182367-47-0
UNII
4O87Q44KNC
EINECS
N/A
Purity
99%
Stability
≥ 2 years