LGD 4033 (Ligandrol, VK5211)

USD $65.00 Bulk Pricing

WARNING: This product is not for human or veterinary use.

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Product Description

Venogen offers certified GMP LGD-4033 Ligandrol for sale in 10mg reference standards.

What is LGD-4033 Ligandrol?

LGD-4033 is a nonsteroidal, orally available selective androgen receptor modulator (SARM), with a molecular weight of 338.248. and a molecular formula of C14H2F6N2O. It is the subject of ongoing scientific attention as an agent to increase lean muscle mass and bone mineral density, with less risk of potential side effects compared to alternative androgen receptor chemicals (e.g. prostate hypertrophy) [1].

Modes of action

LGD-4033 is a member of a class of drugs known as ligand pharmaceuticals. Studies have shown that it binds to androgen receptors (AR) in a tissue selective fashion [1]. It is well-know that AR stimulation benefits muscle growth and bone density. These are known as anabolic effects. Clinical trials are underway to assess its ability to stimulate the synthesis of proteins to build muscle tissue, via a downstream signaling pathway. If it meets the required criteria for FDA approval, this anabolic activity could lead to its future use in the treatment of sarcopenia (wasting of muscles) [2]. Preclinical models also predict positive effects on bone mineral density [1]. It may therefore be used to treat osteoporosis (loss of mass in bones) in humans someday.

Animal Research

A 2020 study in rats observed “beneficial effects … on the muscle structure and metabolism”. However it also observed less tissue selectivity when the dose was increased [3].

Human Research

A 2010 study found that human consumption of LGD-4033 increased physical performance and lean body mass, and noted its long elimination half-life and a lack of negative side effects [1].

A 2020 case study documented liver toxicity following use of LGD-4033 (10mg daily) without medical supervision, similarly to the common misuse of androgen receptor chemicals [4].

Why buy Ligandrol online through Venogen?

All Venogen chemicals have been independently audited by batch and produced within a GMP facility. Venogen is a solid choice if you are looking to buy LGD-4033 online (GMP produced). We are a long-established vendor of analytical research chemicals for laboratory research use. Our products are of the highest quality, and we are proud of our fast shipping and excellent customer service. We have quality LGD 4033 for sale with a high product purity.

Disclaimer

We recommend to buy LGD 4033 online for laboratory research use only. Although researchers demonstrated that human use of this drug may have beneficial effects on the human body in clinical studies, the studies are inconclusive within a proper medical setting and conducted for research purposes only. We offer LGD4033 for sale online as an experimental compound that is not intended for Human or Veterinarian use.

References

[1] Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. The Journals of Gerontology: Series A. 2010;68(1):87-95. doi:10.1093/gerona/gls078

[2] Furrer R, Handschin C. Muscle wasting diseases: Novel targets and treatments. Annual Review of Pharmacology and Toxicology. 2019;59(1):315-339. doi:10.1146/annurev-pharmtox-010818-021041

[3] Roch PJ, Henkies D, Carstens JC, et al. Ostarine and ligandrol improve muscle tissue in an ovariectomized rat model. Frontiers in Endocrinology. 2020;11. doi:10.3389/fendo.2020.556581

[4] Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (lgd-4033)-induced liver injury. ACG Case Reports Journal. 2020;7(6). doi:10.14309/crj.0000000000000370

Technical Information and Resources

 

Formula Weight: 338.3
Molecular formula: C14H12F6N2O
λmax: 224, 295 nm
InChIKey: OPSIVAKKLQRWKC-VXGBXAGGSA-N
Pubchem Compund ID: 44137686

Product Information

CAS
1165910-22-4
UNII
1EJT54415A
EINECS
N/A
Purity
99%
Stability
≥ 2 years